HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-(Piperidin-3-ylamino)nicotinonitrile hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 3-[(5-cyanopyridin-2-yl)amino]piperidine-1-carboxylate | HCID 57911756 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-(Piperidin-3-ylamino)nicotinonitrile hydrochloride | HCID 67060338 | — |
Reaction Steps
2.24 g (7.4 mmol) of tert-butyl 3-[(5-cyanopyridin-2-yl)amino]piperidine-1-carboxylate (Example 8A) were dissolved in 4.3 ml of a hydrochloric acid solution in dioxane (4 M) and stirred at RT for 3 h. On completion of reaction, the solvent was removed completely. 1.74 g (90% of theory) of the product were obtained in solid form.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08664246B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-fa9b35ad63c145c68433a721ed94d0ce |
| Source note | uspto-grants-2014_03 |