Hydrochloric Acid → 2-Amino-6-(piperidin-3-ylamino)pyridine-3-carbonitrile hydrochloride

Participants

Reaction Steps

2.00 g (6.3 mmol) of tert-butyl 3-[(6-amino-5-cyanopyridin-2-yl)amino]piperidine-1-carboxylate (Example 9A) were dissolved in 40 ml of a hydrochloric acid solution in dioxane (4 M) and stirred at RT for 2 h. On completion of reaction, the solvent was concentrated by half, and 20 ml of diethyl ether were added. The precipitate was filtered off and dried. 1.80 g (100% of theory) of the product were obtained in solid form.

Provenance & Evidence