HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Nitro-N6-(piperidin-3-yl)pyridine-2,6-diamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 3-[(6-amino-5-nitropyridin-2-yl)amino]piperidine-1-carboxylate | HCID 57911762 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Nitro-N6-(piperidin-3-yl)pyridine-2,6-diamine hydrochloride | HCID 68987419 | — |
Reaction Steps
610 mg (1.62 mmol) of tert-butyl 3-[(6-amino-5-nitropyridin-2-yl)-amino]piperidine-1-carboxylate (Example 14A) were dissolved in 40 ml of a hydrochloric acid solution in dioxane (4 M) and stirred at RT for 30 min. On completion of reaction, the solvent was removed completely. 662 mg of the crude product were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08664246B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-41e248be34aa4058b2bf9fb930698be1 |
| Source note | uspto-grants-2014_03 |