Hydrochloric Acid → HCID 68987419, compound

HRID 1183000Notes

Reaction equation

HRID 1183000 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH:9]2[CH2:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]2)[CH:5]=[CH:4][C:3]=1[N+:22]([O-:24])=[O:23].[ClH:25]>O1CCOCC1>[ClH:25].[N+:22]([C:3]1[C:2]([NH2:1])=[N:7][C:6]([NH:8][CH:9]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10]2)=[CH:5][CH:4]=1)([O-:24])=[O:23]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57911762Tert-butyl 3-[(6-amino-5-nitropyridin-2-yl)amino]piperidine-1-carboxylate

Product 1

HCID 68987419HCID 68987419, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

610 mg (1.62 mmol) of tert-butyl 3-[(6-amino-5-nitropyridin-2-yl)-amino]piperidine-1-carboxylate (Example 14A) were dissolved in 40 ml of a hydrochloric acid solution in dioxane (4 M) and stirred at RT for 30 min. On completion of reaction, the solvent was removed completely. 662 mg of the crude product were obtained.

Workup

  1. customOn completion of reaction
  2. customthe solvent was removed completely

Sources & evidence

ORD record
ord-41e248be34aa4058b2bf9fb930698be1
Source dataset
uspto-grants-2014_03
Patent number
US08664246B2

Reaction notes

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