反应详情

500 mg (1.90 mmol) of 2-chloro-6-(2-methoxyphenyl)pyridine-3-carboxylic acid were initially charged in a mixture of 20 ml of methanol and 8 ml of toluene and admixed with 8 ml (16 mmol) of a 2 molar solution of trimethylsilyldiazomethane in hexane. The mixture was stirred at RT for 15 h and then 1 ml of acetic acid was added. The solvent was removed fully under reduced pressure, and the resulting solid was used without further purification. 502 mg (87% of theory) of the product were obtained.

1. customThe solvent was removed fully under reduced pressure
2. customthe resulting solid was used without further purification
3. custom502 mg (87% of theory) of the product were obtained