HRID1183010

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID962

Water

H2O

HCID14798

Sodium Hydroxide

HNaO

结构：COC(=O)c1ccc(-c2ccc(Cl)cc2Cl)nc1N1CCCC(Nc2ccc(C(=O)C(F)(F)F)c(N)n2)C1.Cl

HCID86656325

未命名化合物

PRODUCTS

生成物

结构：Cl.Nc1nc(NC2CCCN(c3nc(-c4ccc(Cl)cc4Cl)ccc3C(=O)O)C2)ccc1C(=O)C(F)(F)F

HCID86656326

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8071

未命名化合物

PROCEDURE

实验过程

220 mg (0.36 mmol) of methyl 2-(3-{[6-amino-5-(trifluoroacetyl)pyridin-2-yl]amino}piperidin-1-yl)-6-(2,4-dichlorophenyl)pyridine-3-carboxylate hydrochloride (Example 8) were dissolved in 10 ml of 1,2-dimethoxyethane, and 4.4 ml of water were added. Then 43 mg (1.1 mmol) of sodium hydroxide were added and the mixture was stirred at RT for 30 min. For workup, 35 ml of 2 N hydrochloric acid were added and the precipitate which formed was filtered off with suction. 180 mg (75% of theory) of the product were obtained in solid form.

WORKUP

后处理

customthe precipitate which formed
filtrationwas filtered off with suction
custom180 mg (75% of theory) of the product were obtained in solid form

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-177458e0d7e949e399161b4291c244bb
来源数据集: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08664246B2
来源说明: uspto-grants-2014_03

反应 SMILES

Cl.[NH2:2][C:3]1[N:8]=[C:7]([NH:9][CH:10]2[CH2:15][CH2:14][CH2:13][N:12]([C:16]3[C:21]([C:22]([O:24]C)=[O:23])=[CH:20][CH:19]=[C:18]([C:26]4[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][C:27]=4[Cl:33])[N:17]=3)[CH2:11]2)[CH:6]=[CH:5][C:4]=1[C:34](=[O:39])[C:35]([F:38])([F:37])[F:36].O.[OH-].[Na+].Cl>COCCOC>[ClH:32].[NH2:2][C:3]1[N:8]=[C:7]([NH:9][CH:10]2[CH2:15][CH2:14][CH2:13][N:12]([C:16]3[C:21]([C:22]([OH:24])=[O:23])=[CH:20][CH:19]=[C:18]([C:26]4[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][C:27]=4[Cl:33])[N:17]=3)[CH2:11]2)[CH:6]=[CH:5][C:4]=1[C:34](=[O:39])[C:35]([F:38])([F:37])[F:36]