2-Chloro-6-(2-chlorophenyl)-4-(trifluoromethyl)nicotinonitrile → HCID 44625770, compound

HRID 1183012Notes

Reaction equation

HRID 1183012 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]([F:13])([F:12])[F:11])[CH:5]=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])[N:3]=1.Cl.[NH:22]1[CH2:27][CH2:26][CH2:25][CH:24]([NH:28][C:29]2[N:34]=[CH:33][C:32]([C:35]#[N:36])=[CH:31][CH:30]=2)[CH2:23]1>>[Cl:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[C:4]1[N:3]=[C:2]([N:22]2[CH2:27][CH2:26][CH2:25][CH:24]([NH:28][C:29]3[CH:30]=[CH:31][C:32]([C:35]#[N:36])=[CH:33][N:34]=3)[CH2:23]2)[C:7]([C:8]#[N:9])=[C:6]([C:10]([F:13])([F:12])[F:11])[CH:5]=1

Participants

3

Reactant 2

HCID 14772012-Chloro-6-(2-chlorophenyl)-4-(trifluoromethyl)nicotinonitrileHCID 670603386-(Piperidin-3-ylamino)nicotinonitrile hydrochloride

Product 1

HCID 44625770HCID 44625770, compound

Procedure

Analogously to the preparation of Example 20, 60 mg (0.19 mmol) of 2-chloro-6-(2-chlorophenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile and 47 mg (0.19 mmol) of 6-(piperidin-3-ylamino)pyridine-3-carbonitrile hydrochloride (Example 10A) were used to obtain, after separation by means of preparative HPLC (method 13), 61 mg (67% of theory) of the product in solid form.

Workup

  1. customto obtain
  2. customafter separation by means of preparative HPLC (method 13), 61 mg (67% of theory) of the product in solid form

Sources & evidence

ORD record
ord-b4705b2bad3749e4a083ec8fb01874e3
Source dataset
uspto-grants-2014_03
Patent number
US08664246B2

Reaction notes

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