2-Chloro-6-(2-chlorophenyl)-4-(trifluoromethyl)nicotinonitrile → 6-(2-Chlorophenyl)-2-{3-[(5-cyanopyridin-2-yl)amino]piperidin-1-yl}-4-(trifluoromethyl)-pyridine-3-carbonitrile

Participants

Reaction Steps

Analogously to the preparation of Example 20, 60 mg (0.19 mmol) of 2-chloro-6-(2-chlorophenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile and 47 mg (0.19 mmol) of 6-(piperidin-3-ylamino)pyridine-3-carbonitrile hydrochloride (Example 10A) were used to obtain, after separation by means of preparative HPLC (method 13), 61 mg (67% of theory) of the product in solid form.

Provenance & Evidence