反应详情

Sulfuric acid (13 μl) was added to an ethyl acetate solution (5 ml) of 1-ethyl-3,3,5-trimethyl-7-{3-[(pyridin-4-ylmethyl)amino]propoxy}-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione (100 mg, 0.24 mmol), and stirred at room temperature for 15 minutes. The resultant mixture was concentrated to dryness under reduced pressure to thereby obtain 1-ethyl-3,3,5-trimethyl-7-{3-[(pyridin-4-ylmethyl)amino]propoxy}-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione sulfate as a white amorphous solid.

1. concentrationThe resultant mixture was concentrated to dryness under reduced pressure to thereby obtain 1-ethyl-3,3,5-trimethyl-7-{3-[(pyridin-4-ylmethyl)amino]propoxy}-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione sulfate as a white amorphous solid