Oxaloacetic Acid → HCID 178524627, compound

HRID 1183164Notes

Reaction equation

HRID 1183164 reaction equation
S(=O)(=O)(O)O.Cl.[F:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH:14][NH2:15].[C:16](O)(=[O:23])[CH2:17][C:18]([C:20]([OH:22])=[O:21])=O>O>[F:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[N:14]1[C:16]([OH:23])=[CH:17][C:18]([C:20]([OH:22])=[O:21])=[N:15]1

Participants

5

Reactant 3

HCID 970Oxaloacetic AcidHCID 1118Sulfuric AcidHCID 2723910Hydrazine, (2-fluorophenyl)-, hydrochloride (1:1)

Product 1

HCID 178524627HCID 178524627, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
5 °C

Procedure

Sulfuric acid (400 ml) was added slowly to water (400 ml). After cooling to 5° C., 2-fluoro-phenylhydrazine hydrochloride (123 g, 757 mmol) was added resulting in a brown suspension. Then a solution of oxalacetic acid (100 g, 757 mmol) in water (400 ml) was added slowly during a period of 25 min. After 2 h the conversion was complete and the solid was filtered. After washing with water the solid was dried. The product was obtained as light brown solid (151 g, 90%).

Workup

  1. customresulting in a brown suspension
  2. filtrationthe solid was filtered
  3. washAfter washing with water the solid
  4. customwas dried

Sources & evidence

ORD record
ord-e2ee2d29584643c4adda7a1e84298813
Source dataset
uspto-grants-2014_03
Patent number
US08664257B2

Reaction notes

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