Sodium Hydroxide → HCID 67362326, compound

HRID 1183169Notes

Reaction equation

HRID 1183169 reaction equation
C[O:2][C:3]([C:5]1[CH:9]=[C:8]([O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[N:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])[N:6]=1)=[O:4].[OH-].[Na+]>CO>[CH:12]1([CH2:11][O:10][C:8]2[N:7]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[F:21])[N:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:9]=2)[CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67362940HCID 67362940, compound

Product 1

HCID 67362326HCID 67362326, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The crude compound obtained in step 1 was dissolved in 10 ml of methanol. 1.4 ml of an aqueous 1 M solution of sodium hydroxide were added and the mixture was stirred overnight at room temperature. The solvent was removed in vacuo and the residue purified by preparative HPLC to give 102 mg (58%) of the title compound

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue purified by preparative HPLC

Sources & evidence

ORD record
ord-b9687e65b3084772ba68d088d01d04eb
Source dataset
uspto-grants-2014_03
Patent number
US08664257B2

Reaction notes

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