Cesium carbonate → HCID 67363573, compound

HRID 1183179Notes

Reaction equation

HRID 1183179 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([OH:13])=[CH:11][C:10]([C:14]([OH:16])=[O:15])=[N:9]1.C(=O)([O-])[O-].[Cs+].[Cs+].[N:23]1([C:28](Cl)=[O:29])[CH2:27][CH2:26][CH2:25][CH2:24]1>C1COCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([O:13][C:28]([N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)=[O:29])=[CH:11][C:10]([C:14]([OH:16])=[O:15])=[N:9]1

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 709371-Pyrrolidinecarbonyl chlorideHCID 178524627HCID 178524627, compound

Product 1

HCID 67363573HCID 67363573, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

150 mg (0.675 mmol) of 1-(2-fluoro-phenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid were dissolved in 5 ml of THF. 440 mg (1.35 mmol) of cesium carbonate and 90.2 mg (0.675 mmol) of pyrrolidine-1-carbonyl chloride were added and the mixture was heated to 50° C. for 4 h. Then the mixture was filtrated and the filtrate containing the title compound directly used in the next step.

Workup

  1. filtrationThen the mixture was filtrated
  2. additionthe filtrate containing the title compound

Sources & evidence

ORD record
ord-a1c1de5689564343ac9bb41a3173cb25
Source dataset
uspto-grants-2014_03
Patent number
US08664257B2

Reaction notes

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