Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 67361928 | HCID 67361928 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 67363320 | HCID 67363320 | 100% |
Reaction Steps
The crude 4-chloro-1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester obtained (330 mg, 1.16 mmol) obtained in step 1 was dissolved in 6 ml of dioxane and 5.8 ml of an aqueous 1 M solution of lithium hydroxide were added. The mixture was stirred for 30 min at 56° C. Acidic aqueous work-up gave 320 mg (100%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08664257B2 |
|---|
| Source dataset | uspto-grants-2014_03 |
|---|
| ORD ID | ord-3b5c84517cb24d61b6dbe2f612f08f4e |
|---|
| Source note | uspto-grants-2014_03 |
|---|
