Lithium Hydroxide → HCID 67363320, compound

HRID 1183183Notes

Reaction equation

HRID 1183183 reaction equation
C[O:2][C:3]([C:5]1[C:9]([Cl:10])=[C:8]([O:11][CH3:12])[N:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[F:19])[N:6]=1)=[O:4].[OH-].[Li+]>O1CCOCC1>[Cl:10][C:9]1[C:5]([C:3]([OH:4])=[O:2])=[N:6][N:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[F:19])[C:8]=1[O:11][CH3:12]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 67361928HCID 67361928, compound

Product 1

HCID 67363320HCID 67363320, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
56 °C

Procedure

The crude 4-chloro-1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester obtained (330 mg, 1.16 mmol) obtained in step 1 was dissolved in 6 ml of dioxane and 5.8 ml of an aqueous 1 M solution of lithium hydroxide were added. The mixture was stirred for 30 min at 56° C. Acidic aqueous work-up gave 320 mg (100%) of the title compound.

Workup

  1. customobtained in step 1

Sources & evidence

ORD record
ord-3b5c84517cb24d61b6dbe2f612f08f4e
Source dataset
uspto-grants-2014_03
Patent number
US08664257B2

Reaction notes

Loading…