HCID 67362336, compound → HCID 67363334, compound

HRID 1183187Notes

Reaction equation

HRID 1183187 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([O:13][CH:14]([CH3:16])[CH3:15])=[CH:11][C:10]([C:17]([O:19]C)=[O:18])=[N:9]1>[OH-].[Na+]>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([O:13][CH:14]([CH3:16])[CH3:15])=[CH:11][C:10]([C:17]([OH:19])=[O:18])=[N:9]1

Participants

3

Reactant 1

HCID 67362336HCID 67362336, compound

Product 1

HCID 67363334HCID 67363334, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
40 °C

Procedure

The crude methyl 1-(2-fluoro-phenyl)-5-isopropoxy-1H-pyrazole-3-carboxylate obtained in step 1 was dissolved in 6 ml of MOH, 2 ml of an aqueous 1 M solution of sodium hydroxide were added, and the mixture was stirred for 5 h at 40° C. The solvent was removed and the residue subjected to acidic aqueous work-up to give 70% of the title compound.

Workup

  1. additionwere added
  2. customThe solvent was removed

Sources & evidence

ORD record
ord-06f60068705c4472a3312f30eaac76dd
Source dataset
uspto-grants-2014_03
Patent number
US08664257B2

Reaction notes

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