Lithium Hydroxide → HCID 67363376, compound

Participants

Reaction Steps

100 mg (0.3 mmol) of 5-(3,3-dimethyl-2-oxo-butoxy)-1-(2-fluoro-phenyl)-1H-pyrazole-3-carboxylic acid methyl ester were dissolved in 5 ml of MOH. 0.7 mmol of lithium hydroxide and 2 ml of water were added and the mixture stirred overnight at room temperature. The solvent was removed in vacuo and the residue subjected to aqueous work-up with a 10% solution of citric acid and DCM. The organic phase was dried and the solvent removed in vacuo to give the title compound.

Provenance & Evidence