Lithium Hydroxide → HCID 67363376, compound

HRID 1183190Notes

Reaction equation

HRID 1183190 reaction equation
C[O:2][C:3]([C:5]1[CH:9]=[C:8]([O:10][CH2:11][C:12](=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14])[N:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])[N:6]=1)=[O:4].[OH-].[Li+]>O>[CH3:14][C:13]([CH3:16])([CH3:15])[C:12](=[O:17])[CH2:11][O:10][C:8]1[N:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])[N:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:9]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 67362631HCID 67362631, compound

Product 1

HCID 67363376HCID 67363376, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

100 mg (0.3 mmol) of 5-(3,3-dimethyl-2-oxo-butoxy)-1-(2-fluoro-phenyl)-1H-pyrazole-3-carboxylic acid methyl ester were dissolved in 5 ml of MOH. 0.7 mmol of lithium hydroxide and 2 ml of water were added and the mixture stirred overnight at room temperature. The solvent was removed in vacuo and the residue subjected to aqueous work-up with a 10% solution of citric acid and DCM. The organic phase was dried and the solvent removed in vacuo to give the title compound.

Workup

  1. customThe solvent was removed in vacuo
  2. customThe organic phase was dried
  3. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-f2df8a9a3ac44daf8aa0e5bd8e30a658
Source dataset
uspto-grants-2014_03
Patent number
US08664257B2

Reaction notes

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