5-(4-Bromophenyl)-3-methylisoxazol-4-amine → [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-{1-methyl-2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-ethyl}-amine

HRID 1183351Notes

Reaction equation

HRID 1183351 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[NH2:14])=[CH:4][CH:3]=1.[F:15][C:16]([F:36])([F:35])[C:17]1[CH:34]=[CH:33][C:20]([CH2:21][O:22][C:23]2[CH:28]=[CH:27][C:26]([CH2:29][C:30](=O)[CH3:31])=[CH:25][CH:24]=2)=[CH:19][CH:18]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[NH:14][CH:30]([CH3:31])[CH2:29][C:26]2[CH:27]=[CH:28][C:23]([O:22][CH2:21][C:20]3[CH:33]=[CH:34][C:17]([C:16]([F:15])([F:35])[F:36])=[CH:18][CH:19]=3)=[CH:24][CH:25]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 582185375-(4-Bromophenyl)-3-methylisoxazol-4-amineHCID 665776531-[4-(4-Trifluoromethyl-benzyloxy)-phenyl]-propan-2-one

Product 1

HCID 66577685[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-{1-methyl-2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-ethyl}-amine

Procedure

Prepared according to the procedure described in Example 36, Step 2, using 5-(4-bromo-phenyl)-3-methyl-isoxazol-4-ylamine and 1-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-propan-2-one.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8dac7202b14e4296ad430bc928f326ae
Source dataset
uspto-grants-2014_03
Patent number
US08664220B2

Reaction notes

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