4-(2-Ethoxycarbonylethyl)benzeneboronic acid → 3-(4'-{4-[(1-Benzyl-1H-[1,2,3]triazol-4-yl)-hydroxy-methyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-propionic acid ethyl ester

HRID 1183362Notes

Reaction equation

HRID 1183362 reaction equation
[CH2:1]([N:8]1[CH:12]=[C:11]([CH:13]([C:15]2[C:16]([CH3:27])=[N:17][O:18][C:19]=2[C:20]2[CH:25]=[CH:24][C:23](Br)=[CH:22][CH:21]=2)[OH:14])[N:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:28]([O:30][C:31]([CH2:33][CH2:34][C:35]1[CH:40]=[CH:39][C:38](B(O)O)=[CH:37][CH:36]=1)=[O:32])[CH3:29]>>[CH2:28]([O:30][C:31](=[O:32])[CH2:33][CH2:34][C:35]1[CH:40]=[CH:39][C:38]([C:23]2[CH:24]=[CH:25][C:20]([C:19]3[O:18][N:17]=[C:16]([CH3:27])[C:15]=3[CH:13]([C:11]3[N:10]=[N:9][N:8]([CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[CH:12]=3)[OH:14])=[CH:21][CH:22]=2)=[CH:37][CH:36]=1)[CH3:29]

Participants

3

Reactant 2

HCID 38517004-(2-Ethoxycarbonylethyl)benzeneboronic acidHCID 66579249HCID 66579249, compound

Product 1

HCID 665793873-(4'-{4-[(1-Benzyl-1H-[1,2,3]triazol-4-yl)-hydroxy-methyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-propionic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 10, using (1-benzyl-1H-[1,2,3]triazol-4-yl)-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol and [4-(2-ethoxycarbonylethyl)phenyl]boronic acid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b989d9a3b07b429385b807b7fe418099
Source dataset
uspto-grants-2014_03
Patent number
US08664220B2

Reaction notes

Loading…