4-(2-Ethoxycarbonylethyl)benzeneboronic acid → 3-[4'-(4-Formyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-propionic acid ethyl ester

HRID 1183366Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]=[O:15])=[CH:4][CH:3]=1.[CH2:16]([O:18][C:19]([CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1)=[O:20])[CH3:17]>>[CH2:16]([O:18][C:19](=[O:20])[CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26]([C:2]2[CH:7]=[CH:6][C:5]([C:8]3[O:12][N:11]=[C:10]([CH3:13])[C:9]=3[CH:14]=[O:15])=[CH:4][CH:3]=2)=[CH:25][CH:24]=1)[CH3:17]

Participants

Reactant 2

HCID 38517004-(2-Ethoxycarbonylethyl)benzeneboronic acid

HCID 821337925-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde

Product 1

HCID 866790933-[4'-(4-Formyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-propionic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 10, using 5-(4-bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde and [4-(2-ethoxycarbonylethyl)phenyl]boronic acid.

Workup

customPrepared

Sources & evidence

ORD record: ord-2ff868ba139f4c8493fced233a271b2c
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08664220B2

Reaction notes

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