2-Bromo-6-phenylpyridine → {4'-[3-Methyl-4-(6-phenyl-pyridin-2-ylamino)-isoxazol-5-yl]-biphenyl-4-yl}-acetic acid ethyl ester

HRID 1183406Notes

Reaction equation

HRID 1183406 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[O:22][N:21]=[C:20]([CH3:23])[C:19]=3[NH2:24])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1)[CH3:2].Br[C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[N:28]=1>>[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[O:22][N:21]=[C:20]([CH3:23])[C:19]=3[NH:24][C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([C:33]4[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=4)[N:28]=3)=[CH:14][CH:13]=2)=[CH:10][CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 5686792-Bromo-6-phenylpyridineHCID 66577589Ethyl 2-(4'-(4-amino-3-methylisoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acetate

Product 1

HCID 66577857{4'-[3-Methyl-4-(6-phenyl-pyridin-2-ylamino)-isoxazol-5-yl]-biphenyl-4-yl}-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 68, Step 2, using [4′-(4-amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-acetic acid ethyl ester and 2-bromo-6-phenyl-pyridine.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b32aff6327274181a6b2da83c655a29c
Source dataset
uspto-grants-2014_03
Patent number
US08664220B2

Reaction notes

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