HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 66577781, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 3-Bromobenzoic acid | HCID 11456 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 1-[4'-(4-Amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester | HCID 66577195 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 66577781 | HCID 66577781 | — |
Reaction Steps
1-[4′-(4-Amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester (0.181 g, 0.5 mmol), 3-bromo-benzoic acid (0.100 g, 0.5 mmol), O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyl uronium hexafluorophosphate (0.228 g, 0.6 mmol) and N-methylmorpholine (0.110 mL, 1.0 mmol) were combined in DMF and stirred at room temperature for 2 days. The reaction was submitted to standard aqueous workup and purified by silica gel chromatography to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08664220B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-b051fcca7eb3441e949ad6dbaeb9a85e |
| Source note | uspto-grants-2014_03 |