2-Bromo-6-phenylpyridine → HCID 66577818, compound

HRID 1183483Notes

Reaction equation

HRID 1183483 reaction equation
[CH2:1]([O:3][C:4](=[O:26])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[O:23][N:22]=[C:21]([CH3:24])[C:20]=3[NH2:25])=[CH:15][CH:14]=2)=[CH:9][CH:8]=1)[CH3:2].Br[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[N:29]=1>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[CH2:1]([O:3][C:4](=[O:26])[CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[O:23][N:22]=[C:21]([CH3:24])[C:20]=3[NH:25][C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([C:34]4[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=4)[N:29]=3)=[CH:15][CH:14]=2)=[CH:11][CH:12]=1)[CH3:2]

Participants

5

Reactant 2

HCID 5686792-Bromo-6-phenylpyridineHCID 66577725HCID 66577725, compound

Product 1

HCID 66577818HCID 66577818, compound

Reagents, catalysts & solvents 2

HCID 167845palladium(II) acetateCatalystHCID 9811564Bis(dibenzylideneacetone)palladiumCatalyst

Procedure

Prepared according to the procedure described in Example 68, Step 2, using 3-[4′-(4-amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-propionic acid ethyl ester and 2-bromo-6-phenyl-pyridine. Additionally, palladium(II) acetate was used as the catalyst in place of tris(dibenzylideneacetone)dipalladium(0).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8f20f48d0a3245f68ed0025284f943fc
Source dataset
uspto-grants-2014_03
Patent number
US08664220B2

Reaction notes

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