反应详情

The compound obtained in Example 1-1 (200.6 mg) was added with methanol (2 ml), THF (2 ml), and 1 mol/l aqueous solution of sodium hydroxide (2 ml), and the mixture was stirred for one day at room temperature. After the completion of the reaction, the solvent was removed by distillation and water (5 ml) was added. Aqueous solution of hydrochloric acid (1 mol/l) was added dropwise to the resulting solution to adjust the pH to 3. The deposited crystals were collected by filtration and dried to obtain the title compound (123.2 mg) as colorless crystals.

1. customAfter the completion of the reaction
2. customthe solvent was removed by distillation and water (5 ml)
3. additionwas added
4. additionAqueous solution of hydrochloric acid (1 mol/l) was added dropwise to the resulting solution
5. filtrationThe deposited crystals were collected by filtration
6. customdried