反应详情

The compound obtained in Example 8-3 (83.2 mg) was dissolved in THF (0.8 ml) and methanol (0.8 ml). After the addition of 1 N aqueous solution of sodium hydroxide (0.8 ml), the mixture was stirred for 35 minutes at room temperature. After the reaction, the solvent was removed by distillation and the residue was dissolved in distilled water. Aqueous solution of hydrochloric acid (1 mol/l) was added to the solution to adjust the pH to 3-4. The settled-down oily product was extracted with chloroform, washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was removed by distillation and the residue was dried under vacuum to obtain the title compound (78.7 mg) as colorless oil.

1. customAfter the reaction
2. customthe solvent was removed by distillation
3. dissolutionthe residue was dissolved in distilled water
4. additionAqueous solution of hydrochloric acid (1 mol/l) was added to the solution
5. extractionThe settled-down oily product was extracted with chloroform
6. washwashed with saturated brine
7. dry with materialdried over anhydrous sodium sulfate
8. customThe solvent was removed by distillation
9. customthe residue was dried under vacuum