HCID 24814178, compound → HCID 24814179, compound

HRID 1183788Notes

Reaction equation

HRID 1183788 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]([C:20]2[CH:25]=[CH:24][C:23]([CH2:26][OH:27])=[CH:22][CH:21]=2)[C:10]2[CH:15]=[CH:14][C:13]([CH2:16][OH:17])=[C:12]([O:18][CH3:19])[CH:11]=2)=[CH:5][CH:4]=1>ClCCl.O=[Mn]=O>[CH:2]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([C:20]2[CH:21]=[CH:22][C:23]([CH:26]=[O:27])=[CH:24][CH:25]=2)[C:10]2[CH:15]=[CH:14][C:13]([CH:16]=[O:17])=[C:12]([O:18][CH3:19])[CH:11]=2)=[CH:5][CH:4]=1)=[O:1]

Participants

4

Reactant 1

HCID 24814178HCID 24814178, compound

Product 1

HCID 24814179HCID 24814179, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

MnO2 (40 mg, 444 μmol) is added to a solution of compound 8 (27 mg, 74 μmol) in dichloromethane (2 ml). The suspension obtained is stirred for 48 hours at room temperature and then it is filtered. The solid obtained is washed with dichloromethane. The mother liquors are then concentrated to give 25 mg of compound 9 in the form of a yellow solid (yield: 91%).

Workup

  1. customThe suspension obtained
  2. filtrationit is filtered
  3. customThe solid obtained
  4. washis washed with dichloromethane
  5. concentrationThe mother liquors are then concentrated

Sources & evidence

ORD record
ord-0c823d6342904c36835ae5526b2862ec
Source dataset
uspto-grants-2014_03
Patent number
US08664400B2

Reaction notes

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