Potassium Carbonate → HCID 54478685, compound

HRID 1183870Notes

Reaction equation

HRID 1183870 reaction equation
Br[CH2:2][CH2:3][C:4]([O:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][C:17]([C:20]([C:22]([OH:40])([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([O:31][CH2:32][CH2:33][O:34][C:35](=[O:39])[CH2:36][CH2:37]Br)=[CH:27][CH:26]=2)[CH3:23])=[O:21])([OH:19])[CH3:18])=[CH:12][CH:11]=1)=[O:5].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[C:4]([O:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:16][C:17]([C:20]([C:22]([OH:40])([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([O:31][CH2:32][CH2:33][O:34][C:35](=[O:39])[CH:36]=[CH2:37])=[CH:27][CH:26]=2)[CH3:23])=[O:21])([OH:19])[CH3:18])=[CH:14][CH:15]=1)(=[O:5])[CH:3]=[CH2:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 68741370HCID 68741370, compound

Product 1

HCID 54478685HCID 54478685, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

5.2 g (14.5 mmol) 4-(2-(3-bromopropionyloxy)ethoxy)phenyl-2-hydroxy-2-propyl ketone was dissolved in 45 ml acetone. 30 mg BHT and 3.0 g (21.75 mmol) K2CO3 were added and the reaction mixture was refluxed for 5 hours. The reaction mixture was allowed to cool down to room temperature and the inorganic salts were removed by filtration. The solvent was removed under reduced pressure and the residue was treated with 50 ml n.-hexane. 4-(2-acryloyloxyethoxy)phenyl-2-hydroxy-2-propyl ketone was isolated by filtration. 3 g of 4-(2-acryloyloxyethoxy)phenyl-2-hydroxy-2-propyl ketone (75%) was isolated as a white crystalline compound.

Workup

  1. temperaturethe reaction mixture was refluxed for 5 hours
  2. customthe inorganic salts were removed by filtration
  3. customThe solvent was removed under reduced pressure
  4. additionthe residue was treated with 50 ml n

Sources & evidence

ORD record
ord-e420c04df15946da8e50588e0e7d7342
Source dataset
uspto-grants-2014_03
Patent number
US08664431B2

Reaction notes

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