反应详情

温度

80 °C

Commercially available 2-picolylamine (0.625 ml) was dissolved in toluene (15 ml) and diisopropylethylamine (0.715 ml) was added. After the addition of the compound obtained in Example 9-1 (499.7 mg), the mixture was stirred for two days at 80° C. After the reaction, toluene was added. The solution was washed with distilled water and saturated brine, and dried over anhydrous sodium sulfate. The solvent was removed by istillation under reduced pressure, and the residue was purified by silica gel column chromatography (25 g, chloroform/methanol=25/1) to obtain the title compound (400.1 mg) as light brown oil.

1. additionwas added
2. washThe solution was washed with distilled water and saturated brine
3. dry with materialdried over anhydrous sodium sulfate
4. customThe solvent was removed by istillation under reduced pressure
5. customthe residue was purified by silica gel column chromatography (25 g, chloroform/methanol=25/1)