Trifluoroacetic acid → HCID 178448539, compound

HRID 1184316Notes

Reaction equation

HRID 1184316 reaction equation
[CH2:1]([N:5]1[CH2:9][CH2:8][N:7]([CH3:10])[C:6]1=[CH2:11])[CH2:2][CH2:3][CH3:4].[F:12][C:13]([F:18])([F:17])[C:14]([OH:16])=[O:15]>C(OCC)C>[CH2:1]([N+:5]1[CH:9]=[CH:8][N:7]([CH3:10])[C:6]=1[CH3:11])[CH2:2][CH2:3][CH3:4].[F:12][C:13]([F:18])([F:17])[C:14]([O-:16])=[O:15]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57988737HCID 57988737, compound

Product 1

HCID 178448539HCID 178448539, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
-78 °C

Procedure

1.84 ml (12.09 mmol) 1-n-butyl-3-methyl-2-methylene imidazoline is added to a solution of 1.38 g (12.09 mmol) trifluoroacetic acid in diethylether cooled to −78° C. by means of a syringe. The reaction mixture is slowly warmed to room temperature, wherein a white solid is formed and is stirred overnight at room temperature. Subsequently, all volatile components are removed in vacuum; the residue is washed with 20 ml hexane and, subsequently dried in vacuum. The desired product is obtained as a white solid, which can be recrystallized from dichloromethane.

Workup

  1. temperatureThe reaction mixture is slowly warmed to room temperature
  2. customwherein a white solid is formed
  3. customSubsequently, all volatile components are removed in vacuum
  4. washthe residue is washed with 20 ml hexane
  5. customsubsequently dried in vacuum

Sources & evidence

ORD record
ord-26c184f482034b08b11faa246f2b8e0a
Source dataset
uspto-grants-2014_03
Patent number
US08669114B2

Reaction notes

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