Formic Acid → HCID 86690134, compound

HRID 1184341Notes

Reaction equation

HRID 1184341 reaction equation
[CH:1]([OH:3])=O.[F:4][C:5]1([F:22])[O:10][C:9]2[CH:11]=[C:12]([F:17])[C:13]([NH:15][NH2:16])=[CH:14][C:8]=2[N:7]([CH2:18][C:19]#[CH:20])[C:6]1=[O:21]>ClCCl>[F:22][C:5]1([F:4])[C:6](=[O:21])[N:7]([CH2:18][C:19]#[CH:20])[C:8]2[CH:14]=[C:13]([NH:15][NH:16][CH:1]=[O:3])[C:12]([F:17])=[CH:11][C:9]=2[O:10]1

Participants

4

Reactant 2

HCID 284Formic AcidHCID 86690131HCID 86690131, compound

Product 1

HCID 86690134HCID 86690134, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Formic acid (0.157 ml, 4.09 mmol) was added to 2,2,7-trifluoro-6-hydrazinyl-4-(prop-2-ynyl)-2H-benzo[b][1,4]oxazin-3(4H)-one (the product of Step 1.7 above, 1.0 g, 3.69 mmol) in dichloromethane at room temperature under stirring. The mixture was then stirred overnight at room temperature. The resulting precipitate was isolated over a glass filter and washed with diisopropyl either to yield 858 mg of product (>95% purity), which was used without further purification.

Workup

  1. customThe resulting precipitate was isolated over a glass
  2. filtrationfilter
  3. washwashed with diisopropyl

Sources & evidence

ORD record
ord-135b4a10407a4cc881d2b0be8ef00029
Source dataset
uspto-grants-2014_03
Patent number
US08669208B2

Reaction notes

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