3,4-Dihydro-8-fluoro-2H-1,4-benzoxazine-2-carboxamide → Dihydro-8-chloro-2H-1,4-benzoxazine-2-carboxamide

HRID 1184356Notes

Reaction equation

HRID 1184356 reaction equation
F[C:2]1[C:11]2[O:10][CH:9]([C:12]([NH2:14])=[O:13])[CH2:8][NH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[Cl:15]C1C2OCCNC=2C=CC=1.CCC([O-])=O>>[Cl:15][C:2]1[C:11]2[O:10][CH:9]([C:12]([NH2:14])=[O:13])[CH2:8][NH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 674804863,4-Dihydro-8-fluoro-2H-1,4-benzoxazine-2-carboxamideHCID 866648023,4-dihydro-8-chloro-2H-1,4-benzoxazine 2-ethyl carboxylate

Product 1

HCID 67496535Dihydro-8-chloro-2H-1,4-benzoxazine-2-carboxamide

Procedure

This compound is obtained using the same experimental conditions as those used for the synthesis of intermediate 4b but replacing 3,4-dihydro-8-fluoro-2H-1,4-benzoxazine-2-ethyl carboxylate (5b) with 3,4-dihydro-8-chloro-2H-1,4-benzoxazine-2-ethyl carboxylate (5d), [73268-47-0]. The title compound of formula (4d) is obtained.

Workup

  1. customThis compound is obtained

Sources & evidence

ORD record
ord-9615b7b68524456eb0663878717bdd00
Source dataset
uspto-grants-2014_03
Patent number
US08669250B2

Reaction notes

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