3,4-dihydro-4-methyl-2H-1,4-benzoxazine-2-carboxamide → Dihydro-8-carbamoyl-2H-1,4-benzoxazine-2-methanamine

HRID 1184361Notes

Reaction equation

HRID 1184361 reaction equation
F[C:2]1[C:11]2[O:10][CH:9]([CH2:12][NH2:13])[CH2:8][NH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.CN1C2C=CC=CC=2OC([C:25]([NH2:27])=[O:26])C1>>[C:25]([C:2]1[C:11]2[O:10][CH:9]([CH2:12][NH2:13])[CH2:8][NH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1)(=[O:26])[NH2:27]

Participants

3

Reactant 2

HCID 128265523,4-dihydro-4-methyl-2H-1,4-benzoxazine-2-carboxamideHCID 67497870Dihydro-8-fluoro-2H-1,4-benzoxazine-2-methanamine

Product 1

HCID 67497746Dihydro-8-carbamoyl-2H-1,4-benzoxazine-2-methanamine

Procedure

This compound is obtained following the same experimental conditions as those used for the synthesis of intermediate (2b) but replacing 3,4-dihydro-8-fluoro-2H-1,4-benzoxazine-2-carboxamide (4b) with 3,4-dihydro-4-methyl-2H-1,4-benzoxazine-2-carboxamide (4h). The title compound of formula (2h) is obtained.

Workup

  1. customThis compound is obtained

Sources & evidence

ORD record
ord-8b19fd049afa4c78b431703f966fe0be
Source dataset
uspto-grants-2014_03
Patent number
US08669250B2

Reaction notes

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