反应详情

To a 40 mL vial containing tert-butyl 4-(2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yloxy)piperidine-1-carboxylate 394D (0.223 g, 0.615 mmol) was added 50% solution of TFA in DCM (2.0 mL, 12.98 mmol) to give a clear brown solution. The reaction was monitored by HPLC. At 0.5 hr, the reaction was pulled and concentrated in vacuo, affording the product as a clear, brown oil (0.161 g, 100% yield). ESI-MS: m/z 263.2 (M+H)+.

1. customto give a clear brown solution
2. concentrationconcentrated in vacuo