HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → methyl 2-((((2S,4R)-4-((5-cyclopropylpyrazin-2-yl)oxy)pyrrolidin-2-yl)-methyl)amino)acetate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (2S,4R)-tert-butyl 4-(5-cyclopropylpyrazin-2-yloxy)-2-((2-methoxy-2-oxoethylamino)methyl)pyrrolidine-1-carboxylate | HCID 86680521 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | methyl 2-((((2S,4R)-4-((5-cyclopropylpyrazin-2-yl)oxy)pyrrolidin-2-yl)-methyl)amino)acetate hydrochloride | HCID 86680522 | — |
Reaction Steps
A solution of the product from Example 174E (1.10 g, 2.71 mmol) in dichloromethane (3 mL) was treated with hydrochloric acid in 1,4-dioxane (4 M, 3 mL). The mixture was stirred for 30 minutes, during which time a solid formed. The volatiles were removed in vacuo to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669255B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-e7dfe0eeee784f1f91b683d738a2ceb2 |
| Source note | uspto-grants-2014_03 |