Hydrochloric Acid → HCID 86762293, compound

HRID 1184674Notes

Reaction equation

HRID 1184674 reaction equation
[C:1]([O:9][CH2:10][CH2:11][N:12]([CH2:21][C:22]([O:24]C(C)(C)C)=[O:23])[CH2:13][C:14](=[O:20])[O:15]C(C)(C)C)(=[O:8])/[CH:2]=[CH:3]/[C:4]([O:6][CH3:7])=[O:5].[ClH:29]>O1CCOCC1>[ClH:29].[CH3:7][O:6][C:4](=[O:5])/[CH:3]=[CH:2]/[C:1]([O:9][CH2:10][CH2:11][N:12]([CH2:13][C:14]([OH:20])=[O:15])[CH2:21][C:22]([OH:24])=[O:23])=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86762295HCID 86762295, compound

Product 1

HCID 86762293HCID 86762293, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of 2-(bis(2-(tert-butoxy)-2-oxoethyl)amino)ethyl methyl fumarate (2.52 g, 6.2 mmol) in dioxane (25 ml) was added 2M HCl in dioxane (30 ml) and the mixture stirred for 90 hours. The precipitate was filtered, washed with diethyl ether and dried in a vacuum oven at 55° C. for 18 hours to give (E)-2,2′-((2-((4-methoxy-4-oxobut-2-enoyl)oxy)ethyl)azanediyl)diacetic acid hydrochloride, a white solid (1.31 g, 65%).

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with diethyl ether
  3. customdried in a vacuum oven at 55° C. for 18 hours

Sources & evidence

ORD record
ord-7cd6f73d61b2401b9ac75d932abc7e62
Source dataset
uspto-grants-2014_03
Patent number
US08669281B1

Reaction notes

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