Methanol → 4-(5-Bromo-2,3-dihydrobenzofuran-2-yl)piperidine

HRID 1184697Notes

Reaction equation

HRID 1184697 reaction equation
C(=O)([O-])[O-].[K+].[K+].[Br:7][C:8]1[CH:9]=[CH:10][C:11]2[O:15][CH:14]([CH:16]3[CH2:21][CH2:20][N:19](C(=O)C(F)(F)F)[CH2:18][CH2:17]3)[CH2:13][C:12]=2[CH:28]=1.CO.O>[Cl-].[Na+].O>[Br:7][C:8]1[CH:9]=[CH:10][C:11]2[O:15][CH:14]([CH:16]3[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]3)[CH2:13][C:12]=2[CH:28]=1

Participants

6

Reactant 4

HCID 887MethanolHCID 962WaterHCID 11430Potassium CarbonateHCID 866748871-[4-(5-Bromo-2,3-dihydro-benzofuran-2-yl)-piperidin-1-yl]-2,2,2-trifluoro-ethanone

Product 1

HCID 674691344-(5-Bromo-2,3-dihydrobenzofuran-2-yl)piperidine

Reagents, catalysts & solvents 1

HCID 57417360Sodium chloride; waterSolvent

Procedure

Potassium carbonate (10.17 g) is added to an ice-cooled mixture of 1-[4-(5-bromo-2,3-dihydro-benzofuran-2-yl)-piperidin-1-yl]-2,2,2-trifluoro-ethanone (4.64 g), methanol (120 mL), and water (30 mL). The reaction mixture is stirred over night at room temperature. Brine (150 mL) is added and the mixture is extracted with dichloromethane. The combined organic phases are dried over MgSO4 and concentrated in vacuo. The crude product is used for the next step without further purification. LC (method 2): tR=1.05 min; Mass spectrum (ESI+): m/z=282, 284 [M+H]+.

Workup

  1. temperaturecooled
  2. extractionthe mixture is extracted with dichloromethane
  3. dry with materialThe combined organic phases are dried over MgSO4
  4. concentrationconcentrated in vacuo
  5. customThe crude product is used for the next step without further purification

Sources & evidence

ORD record
ord-fc0313d771d14245820881afe5a8fb4c
Source dataset
uspto-grants-2014_03
Patent number
US08669271B2

Reaction notes

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