Isopropyl chloroformate → 4-(5-Chloro-2,3-dihydro-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid isopropyl ester

HRID 1184715Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[CH2:10][CH:9]([CH:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[O:8][C:5]2=[CH:6][N:7]=1.Cl[C:18]([O:20][CH:21]([CH3:23])[CH3:22])=[O:19]>>[CH:21]([O:20][C:18]([N:14]1[CH2:15][CH2:16][CH:11]([CH:9]2[O:8][C:5]3=[CH:6][N:7]=[C:2]([Cl:1])[CH:3]=[C:4]3[CH2:10]2)[CH2:12][CH2:13]1)=[O:19])([CH3:23])[CH3:22]

Participants

Reactant 2

HCID 7917Isopropyl chloroformate

HCID 866748985-Chloro-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine

Product 1

HCID 866748974-(5-Chloro-2,3-dihydro-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid isopropyl ester

Procedure

The title compound is prepared from 5-chloro-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine and isopropyl chloroformate following a procedure analogous to that described in Example 4. LC (method 7): tR=1.37 min; Mass spectrum (ESI+): m/z=325 [M+H]+.

Sources & evidence

ORD record: ord-f60c09ddffa549f58da5a28e1b475191
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08669271B2

Reaction notes

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