2-Bromo-5-(methylsulfonyl)pyridine → HCID 67973287, compound

HRID 1184730Notes

Reaction equation

HRID 1184730 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]2[CH2:18][C:17]3[CH:19]=[C:20](B4OC(C)(C)C(C)(C)O4)[CH:21]=[CH:22][C:16]=3[O:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[C:33]1[CH:38]=[CH:37][C:36]([S:39]([CH3:42])(=[O:41])=[O:40])=[CH:35][N:34]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([CH:14]2[CH2:18][C:17]3[CH:19]=[C:20]([C:33]4[CH:38]=[CH:37][C:36]([S:39]([CH3:42])(=[O:41])=[O:40])=[CH:35][N:34]=4)[CH:21]=[CH:22][C:16]=3[O:15]2)[CH2:12][CH2:13]1)=[O:7])([CH3:2])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 98994832-Bromo-5-(methylsulfonyl)pyridineHCID 679736294-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 67973287HCID 67973287, compound

Procedure

The title compound is prepared from 4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid tert-butyl ester and 2-bromo-5-methanesulfonyl-pyridine following a procedure analogous to that described in Example 1. LC (method 1): tR=1.41 min; Mass spectrum (ESI+): m/z=459 [M+H]+.

Sources & evidence

ORD record
ord-73a7629d241640e5a1fe008e5a7dabd4
Source dataset
uspto-grants-2014_03
Patent number
US08669271B2

Reaction notes

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