HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-5-(methylsulfonyl)pyridine → 4-[5-(5-Methanesulfonyl-pyridin-2-yl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-5-(methylsulfonyl)pyridine | HCID 9899483 | — |
| Reactant | 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 67973629 | — |
| Product | 4-[5-(5-Methanesulfonyl-pyridin-2-yl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 67973287 | — |
Reaction Steps
The title compound is prepared from 4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid tert-butyl ester and 2-bromo-5-methanesulfonyl-pyridine following a procedure analogous to that described in Example 1. LC (method 1): tR=1.41 min; Mass spectrum (ESI+): m/z=459 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669271B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-73a7629d241640e5a1fe008e5a7dabd4 |
| Source note | uspto-grants-2014_03 |