Methylamine → HCID 67990211, compound

HRID 1184735Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]2[O:32][C:17]3=[CH:18][N:19]=[C:20]([C:22]4[CH:27]=[CH:26][C:25]([C:28]([OH:30])=O)=[CH:24][C:23]=4[F:31])[CH:21]=[C:16]3[CH2:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:33][NH2:34]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]2[O:32][C:17]3=[CH:18][N:19]=[C:20]([C:22]4[CH:27]=[CH:26][C:25]([C:28](=[O:30])[NH:34][CH3:33])=[CH:24][C:23]=4[F:31])[CH:21]=[C:16]3[CH2:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:3])([CH3:2])[CH3:4]

Participants

Reactant 2

HCID 6329Methylamine

HCID 67973511HCID 67973511, compound

Product 1

HCID 67990211HCID 67990211, compound

Procedure

The title compound is prepared from 4-[5-(4-carboxy-2-fluoro-phenyl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester and methylamine following a procedure analogous to that described in Example 26. LC (method 7): tR=1.25 min; Mass spectrum (ESI+): m/z=456 [M+H]+.

Sources & evidence

ORD record: ord-18006d595b004355b04073ea71aed2b6
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08669271B2

Reaction notes

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