HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1184816Generated: November 2, 2026
Hydrochloric Acid → N-(3-amino-4-methylphenyl)-3-(2-cyanopropan-2-yl)benzamide hydrochloride
https://huagongshe.com/reaction/1184816
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-(3-amino-4-methylphenyl)-3-(2-cyanopropan-2-yl)benzamide | HCID 67125542 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-(3-amino-4-methylphenyl)-3-(2-cyanopropan-2-yl)benzamide hydrochloride | HCID 67125541 | 83% |
Reaction Steps
To a solution of N-(3-amino-4-methylphenyl)-3-(2-cyanopropan-2-yl)benzamide 5 (18 g, 61 mmol) in dioxane was added 4N HCl in dioxane (1.1 eq) and stirred at 60° C. for 1 h. After cooling the precipitate was collected to give N-(3-amino-4-methylphenyl)-3-(2-cyanopropan-2-yl)benzamide hydrochloride 6 (16.7 g, 83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08669256B2 |
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| Source dataset | uspto-grants-2014_03 |
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| ORD ID | ord-b3f69f4e685a46269e0eaf24203abe70 |
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| Source note | uspto-grants-2014_03 |
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