HRID1184816

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1N

HCID67125542

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1N.Cl

HCID67125541

未命名化合物

收率 83%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

2 次

CONDITIONS

反应条件

温度: 60 °C

PROCEDURE

实验过程

To a solution of N-(3-amino-4-methylphenyl)-3-(2-cyanopropan-2-yl)benzamide 5 (18 g, 61 mmol) in dioxane was added 4N HCl in dioxane (1.1 eq) and stirred at 60° C. for 1 h. After cooling the precipitate was collected to give N-(3-amino-4-methylphenyl)-3-(2-cyanopropan-2-yl)benzamide hydrochloride 6 (16.7 g, 83%).

WORKUP

后处理

temperatureAfter cooling the precipitate
customwas collected