Hydrochloric Acid → N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-3-(2-(dimethylamino)ethylamino)thieno[2,3-b]pyrazine-6-carboxamide hydrochloride

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Reaction Steps

Compound 96c (8 mg, 0.015 mmol) was dissolved in dioxane (0.5 mL), 4N HCl (1 eq) was added and stirred for 1 h. Evaporated to dryness to give N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-3-(2-(dimethylamino)ethylamino)thieno[2,3-b]pyrazine-6-carboxamide hydrochloride 96d (9 mg, 100%). NMR (400 MHz, DMSO-d6) 1.76 (s, 6H), 2.24 (s, 3H), 2.84 (d, J=4.7 Hz, 6H), 3.33 (dt, J=5.9 Hz and 5.4 Hz, 2H), 3.75 (dt, J=5.9 Hz and 5.4 Hz, 2H), 7.28 (d, J=8.6 Hz, 1H), 7.60 (m, 2H), 7.75 (d, J=7.8 Hz, 1H), 7.86 (d, J=1.6 Hz, 1H), 7.95 (d, J=7.8 Hz, 1H), 8.06 (s, 1H), 8.18 (s, 1H), 8.21 (t, J=5.4 Hz, 1H), 8.32 (s, 1H), 10.09 (br s, 1H), 10.19 (s, 1H), 10.38 (s, 1H).

Provenance & Evidence