HRID1184906

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1NC(=O)c1cc2ncc(NCCN(C)C)nc2s1

HCID67125549

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1NC(=O)c1cc2ncc(NCCN(C)C)nc2s1.Cl

HCID67125561

未命名化合物

收率 100%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

Compound 96c (8 mg, 0.015 mmol) was dissolved in dioxane (0.5 mL), 4N HCl (1 eq) was added and stirred for 1 h. Evaporated to dryness to give N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-3-(2-(dimethylamino)ethylamino)thieno[2,3-b]pyrazine-6-carboxamide hydrochloride 96d (9 mg, 100%). NMR (400 MHz, DMSO-d6) 1.76 (s, 6H), 2.24 (s, 3H), 2.84 (d, J=4.7 Hz, 6H), 3.33 (dt, J=5.9 Hz and 5.4 Hz, 2H), 3.75 (dt, J=5.9 Hz and 5.4 Hz, 2H), 7.28 (d, J=8.6 Hz, 1H), 7.60 (m, 2H), 7.75 (d, J=7.8 Hz, 1H), 7.86 (d, J=1.6 Hz, 1H), 7.95 (d, J=7.8 Hz, 1H), 8.06 (s, 1H), 8.18 (s, 1H), 8.21 (t, J=5.4 Hz, 1H), 8.32 (s, 1H), 10.09 (br s, 1H), 10.19 (s, 1H), 10.38 (s, 1H).

WORKUP

后处理

customEvaporated to dryness

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4725d78070f147dc8c1393725ee8f18d
来源数据集: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08669256B2
来源说明: uspto-grants-2014_03

反应 SMILES

[C:1]([C:3]([C:6]1[CH:7]=[C:8]([CH:37]=[CH:38][CH:39]=1)[C:9]([NH:11][C:12]1[CH:13]=[CH:14][C:15]([CH3:36])=[C:16]([NH:18][C:19]([C:21]2[S:35][C:24]3=[N:25][C:26]([NH:29][CH2:30][CH2:31][N:32]([CH3:34])[CH3:33])=[CH:27][N:28]=[C:23]3[CH:22]=2)=[O:20])[CH:17]=1)=[O:10])([CH3:5])[CH3:4])#[N:2].[ClH:40]>O1CCOCC1>[ClH:40].[C:1]([C:3]([C:6]1[CH:7]=[C:8]([CH:37]=[CH:38][CH:39]=1)[C:9]([NH:11][C:12]1[CH:13]=[CH:14][C:15]([CH3:36])=[C:16]([NH:18][C:19]([C:21]2[S:35][C:24]3=[N:25][C:26]([NH:29][CH2:30][CH2:31][N:32]([CH3:33])[CH3:34])=[CH:27][N:28]=[C:23]3[CH:22]=2)=[O:20])[CH:17]=1)=[O:10])([CH3:5])[CH3:4])#[N:2]