反应详情

温度

50 °C

To a solution of methyl 2-chlorothieno[3,2-b]pyrazine-6-carboxylate 22 (100 mg, 0.437 mmol) in THF (1.8 mL) and ethanol (1.2 mL) was added 2N sodium hydroxide (1.09 mL, 2.19 mmol). The reaction was stirred overnight at 50° C. The reaction mixture was poured in citric acid solution and the resulting precipitate was collected, washed with water and dried to give crude 2-ethoxythieno[2,3-b]pyrazine-6-carboxylic acid (60 mg, 61%). (m/z)=225 (M+H)+.

1. customthe resulting precipitate was collected
2. washwashed with water
3. customdried