HCID 86684069, compound → HCID 73555061, compound

HRID 1185223Notes

Reaction equation

HRID 1185223 reaction equation
COC1C=CC(C[N:8](CC2C=CC(OC)=CC=2)[C:9]2[N:14]=[CH:13][C:12]([C:15]([CH3:19])([CH3:18])[C:16]#[N:17])=[CH:11][CH:10]=2)=CC=1>C(O)(C(F)(F)F)=O>[NH2:8][C:9]1[N:14]=[CH:13][C:12]([C:15]([CH3:19])([CH3:18])[C:16]#[N:17])=[CH:11][CH:10]=1

Participants

3

Reactant 1

HCID 86684069HCID 86684069, compound

Product 1

HCID 73555061HCID 73555061, compoundYield 290.8%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 156b (514 mg, 1.28 mmol) in CF3COOH (15 mL) was stirred at 60° C. for 2 h. After this time the reaction was cooled to room temperature. It was then evaporated under reduced pressure and residue was washed with petroleum ether and ethyl acetate to afford 156c (600 mg, crude) as a yellow solid. MS-ESI: [M+H]+ 162.3

Workup

  1. customIt was then evaporated under reduced pressure and residue
  2. washwas washed with petroleum ether and ethyl acetate

Sources & evidence

ORD record
ord-673e0aa043f84fd49d8e6764629b0296
Source dataset
uspto-grants-2014_03
Patent number
US08669251B2

Reaction notes

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