HCID 86684081, compound → HCID 86684082, compound

HRID 1185233Notes

Reaction equation

HRID 1185233 reaction equation
[F:1][CH:2]([F:11])[N:3]1[N:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[N:4]1>[Pd]>[F:1][CH:2]([F:11])[N:3]1[N:7]=[C:6]([NH2:8])[CH:5]=[N:4]1

Participants

3

Reactant 1

HCID 86684081HCID 86684081, compound

Product 1

HCID 86684082HCID 86684082, compoundYield 81.5%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the procedure of Example 151e, and starting with 159a (300 mg, 1.83 mmol) and 10% palladium on carbon (50% wet, 60 mg) afforded 159b as a yellow liquid (200 mg, 81%). 1H NMR (500 MHz, CDCl3) δ 7.24 (s, 1H), 7.14 (t, J=58.5 Hz, 1H), 4.08 (brs, 2H).

Sources & evidence

ORD record
ord-1b6c647cb73d4cafbf88f20125a939b1
Source dataset
uspto-grants-2014_03
Patent number
US08669251B2

Reaction notes

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