HCID 66855424, compound → 1-Cyclobutoxycarbonylpiperazine

HRID 1185499Notes

Reaction equation

HRID 1185499 reaction equation
[CH:1]1([O:5][C:6]([N:8]2[CH2:13][CH2:12][N:11](C(OCC3C=CC=CC=3)=O)[CH2:10][CH2:9]2)=[O:7])[CH2:4][CH2:3][CH2:2]1>C(OCC)(=O)C.[Pd]>[CH:1]1([O:5][C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[O:7])[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 66855424HCID 66855424, compound

Product 1

HCID 668544701-Cyclobutoxycarbonylpiperazine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A suspension of 5.90 g Piperazine-1,4-dicarboxylic acid benzyl ester cyclobutyl ester and 0.25 g Pd/C (10%) in 50 ml ethyl acetate was stirred under an atmosphere of hydrogen (3 bar) for 12 h. The mixture was filtrated over a plug of Celite, washed with ethyl acetate and the combined wash solutions concentrated to give the title compound as colourless oil. Yield: 3.3 g.

Workup

  1. filtrationThe mixture was filtrated over a plug of Celite
  2. washwashed with ethyl acetate
  3. concentrationthe combined wash solutions concentrated

Sources & evidence

ORD record
ord-10d5a36f69bf49ecbf1c58986e32c356
Source dataset
uspto-grants-2014_03
Patent number
US08669266B2

Reaction notes

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