反应详情

The compound obtained in Example 16-1 (1 g) was dissolved in methanol (10 ml), and 1 mol/l aqueous solution of sodium hydroxide (10 ml) was added. The reaction solution was dissolved in THF (10 ml). After the reaction for 7 hours, the reaction solution was concentrated. The obtained residue was dissolved in water and 1 mol/l hydrochloric acid was gradually added while stirring to obtain a precipitate. The precipitate was collected by filtration through glass filter G4 and washed with water to obtain the title compound (560.1 mg) as a pale yellow solid.

1. customAfter the reaction for 7 hours
2. concentrationthe reaction solution was concentrated
3. dissolutionThe obtained residue was dissolved in water
4. addition1 mol/l hydrochloric acid was gradually added
5. customto obtain a precipitate
6. filtrationThe precipitate was collected by filtration through glass
7. filtrationfilter G4
8. washwashed with water