(S)-4-(4-Benzyl-2H-tetrazol-5-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester → (2S)-2-{[(tert-butoxy)carbonyl]amino}-4-(1H-1,2,3,4-tetrazol-5-yl)butanoic acid

Participants

Reaction Steps

To a solution of 4.63 g (S)-4-(4-benzyl-2H-tetrazol-5-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester in 400 ml ethyl acetate were added 800 mg Pd(OH)2/C (10%) and the suspension stirred under an atmosphere of hydrogen (4 bar) for 12 h. The reaction mixture was filtrated over a plug of Celite® and washed with ethyl acetate. Yield: 2.84 g colorless solid.

Provenance & Evidence